Granulomatous enteritis
Granulomatous enteritis is an apparently rare form of IBD, and is characterized by mucosal infiltration with macrophages. The distribution of granulomata can be patchy. This condition is likely to be the same as regional enteritis in humans, where
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ileal granulomata have been reported.61,62 In cats, a pyogranu- Iomatous transmural inflammation has been associated with FIP infection.
The condition in dogs does have some histological features common to human CD, but intestinal obstruction and fistula formation have not been noted. Conventional therapy for IBD (see above) is usually not effective and the prognosis is guarded, although a combination of surgical resection and anti-inflammatory treatment was reported to be successful in one case.62The colitis is characterized by accumulation of PAS-positive macrophages, although a mixed inflammatory response with T-cells and IgG plasma cells is usually present. The disease is rare and sporadic, and for many years it has been hypothesized that it is infectious in nature, although attempts at disease transmission have failed. However, recently the condition has been reported to be sensitive to enrofloxacin, again suggesting an infectious etiology.37,38
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