Introduction

Primary hypoadrenocorticism (Addison's disease) is more common and can lead to both mineralocorticoid and glucocorticoid deficiency. A few cases present with evidence of glucocorticoid deficiency alone and do not have the typical hyponatremia and hyper­kalemia (atypical Addison). With time, these patients may progress to mineralocorticoid deficiency and develop electrolyte imbal­ances. In secondary hypoadrenocorticism, a deficiency of adrenocorticotropic hormone (ACTH) results in glucocorticoid insuffi­ciency only. These patients do not develop mineralocorticoid deficiency.