Lymphoplasmacytic colitis (LPC)
Some veterinary gastroenterologists claim that LPC is the most common form of IBD, and that it occurs in isolation from LPE. However, this is not generally accepted, and may reflect a historical perspective from before the advent of flexible endoscopy, when it was possible to obtain colonic biopsy specimens through a rigid endoscope, but impossible to obtain SI biopsy specimens except by surgical biopsy.
Thus, the discrepancy may reflect failure to perform upper GI endoscopy at the same time as colonoscopy, failure to recognize LPE histologically, and failure to perform serum folate and cobalamin assays as a marker for occult SI disease in animals with predominantly large bowel diarrhea. However, since the use of endoscopy to obtain SI biopsies has become routine, it has been shown that isolated LPC only occurs occasionally.2The treatment of LPC is similar to that of LPE, but includes dietary modification with fiber and the use of 5-ASA derivatives. Prolongation of remission has also been reported after introduction of a hypoallergenic exclusion diet.
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