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Basic Living Unit of the Body: Cells

All animals are made up of a complex yet unique bunch of living units—cells (Fig. 1.1). It is the cell interconnectedness in living organisms that creates the beauty of complex systems.

Each organ is a group of many different cells that are intercellularly supported through structures.

Interestingly, the surface membrane is a mere 70-100 A thick (0.0000007-0.00001 mm). The average size of cells is around 10-100 μm, or 0.01-0.1 mm in diameter, denoting the fragile nature of the cell and membrane. This identification was made more accessible by discovering an electron micro­scope. Many intracellular organelles like the Golgi complex, endoplasmic reticulum, nucleus, mitochondria, vesicles, and many more organelles or structures were identified.

A typical animal cell consists of nucleus, a cell membrane, and cell cytoplasm. The nucleus is the structure that houses genetic information, generally referred to as DNA, and it controls the actions and the reactions of the cell. The cell membrane, the border of the cell, acts as the gatekeeper. It controls what enters and exits the cell and enables adjacent cells to stick to each other. The cytoplasm is where chemical reactions take place in cells.

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Cells Are Self-destructive

No, this does not imply that cells self-destruct auto­matically. If a cell is injured or has DNA defects, it self­destructs to avoid interfering with other cells.

There are numerous distinct cell types, each with a unique set of capabilities. For instance, cattle maintain an average of 6.3 ? 1012∕L RBCs, with the major purpose of carrying oxygen from the lungs to the respective tissues. At a rough guess, cattle might have around 105-420 trillion cells. One of a kind is nerve cells which have branched endings called dendrites. This is so they can communicate with lots of other nerve cells through electrical impulses. White blood cells (WBCs) enable animals to fight infections.

Their dis­tinctive lobed nucleus can be used to identify them. WBCs have a flexible cytoplasm so that they can engulf pathogens in a process called phagocytosis. Some other WBCs are specialised in producing antibodies, and it is these antibodies fight pathogens.

Though cells have different functions, essential physical characteristics are similar. For instance, in all cells, the reaction of oxygen with carbohydrates, fat, and protein produces the energy necessary for cell function. Additionally, the chemical mechanisms by which nutrients are converted to energy are roughly comparable in all cells. All cells excrete the products of their chemical reactions into the adjoining fluids.

Fig. 1.1 Description of the typical mammalian cell and its components. (Courtesy: BioRender)

Those mentioned above are fundamental features of cells. With the improvements in technology, it is possible to generate an entire animal from a single cell using multiple techniques. For example, cattle cloning was done using the somatic cell nuclear transfer (SCNT) technique, one of the genetic engineering tools. Recently with advancements in designer nucleases, such as transcription activator-like effector nuclease (TALENs), zinc-finger nucleases (ZFNs), and clustered regularly interspaced short palin­dromic repeats/CRISPR-associated protein 9 (CRISPR/ Cas9) made path-breaking discoveries that can create a designer offspring’s, which will be beneficial to maintain elite lineage in animals. Concluding, with recent advancements in genetic engineering, one can anticipate that the agricultural and biomedical applications of geneti­cally engineered animals that have been long envisioned will soon be recognised in the marketplace.

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Source: Das Pradip Kumar, Sejian V., Mukherjee J., Banerjee D. (eds.). Textbook of Veterinary Physiology. Springer,2023. — 795 p.. 2023

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