A big challenge and an alternative
Pap test was not specifically developed to detect neither human cervical lesions nor HPV infection [44]. Moreover, it has not been subjected to a rigorous analysis regarding its sensitivity and specificity; however, it is the accepted test for detecting cytomorphological changes in the cervicovaginal epithelium but not for HPV.
Epidemiological studies show that HPV detection does not necessarily indicate cancer, so it is considered necessary but not enough for CC development [51].On the other hand, the CC research has served to define that prior to this type of invasive lesions, there are precursor or pre-invasive lesions as SIL, thanks to epidemiological studies, it has been determined that less than 10% of women infected with HPV will develop CC [52]. So far, it is unknown what factors are indispensable for the progression of these lesions causing “headaches” among oncologist and gynecologists alike, for nobody knows which SIL will progress to a more aggressive lesion. Many questions result in no concrete answer. Given these facts, the new OMICs area opens the opportunity for the early detection of pre-invasive lesions. Combining analytical and biotechnological procedures as aforementioned will permit the basis for new portable nanosystems.
In summary, our proposals are affordable and accessible for any women and could be an important weapon in this war against CC as a preventive measure deployed by health services, all this granting the public and government departments accept them.
10.