BipotentGonads
The indifferent or bipotent gonads arise, as paired structures, from the central region (mesonephros) within the intermediate mesoderm during the first half of embryonic development.
The PGCs and supporting cells migrate to the genital ridge from the yolk sac situated at the base of the allantois at the posterior end of the primitive streak. Their site of migration determines the development of male and female gonads. The migration of PGCs at medullary and cortical regions of the gonadal ridge leads to the development of the Wolffian duct, which later transformed into male gonads (testes), and the Mullerian duct leads to the development of female gonads (ovaries), respectively (Fig. 18.1). Both the gonads appear on the ventromedial surface of the mesonephros. The supporting cells are developed into steroid-secreting cells, either testisspecific Sertoli cells or ovary-specific follicle (granulosa) cells.18.2
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