Late in the Ovarian Follicular Phase, Luteinizing Hormone Receptors Develop on the GranuIosazWhich Permits the Preovulatory Surge of Luteinizing Hormone to Cause Ovulation

Late in antral follicle development, FSH and estrogens initiate the formation of LH receptors on the granulosa, whereas FSH receptors begin to diminish. Increasing secretion of estrogen by the antral follicle finally results in the initiation of the pre­ovulatory surge of gonadotropins. Thus, in the last stages of development, the follicle falls progressively under the control of LH as it makes its last growth spurt to the point of ovulation.