SPECIES EFFECTS ON LABORATORY METHODS
In order to validate drug concentrations in the biological fluids and tissues of Australian mammals, differences in drug binding to plasma proteins (as discussed in section 2.2.1) between species may require consideration when using enzyme-linked immunosorbent assays (ELISA) that have been validated for use in humans or domestic animal species.
ELISA kits designed to be used with human fluids may require revalidation using the target species’ plasma/ serum or urine. Additionally, species differences in the plasma matrix (such as differences in the type and amount of endogenous matrix constituents) may affect the assay’s sensitivity and selectivity. Various endogenous compounds in the plasma of eucalypt folivores may interfere with drug assays that quantify drug concentrations in biological fluids and tissues by chromatography (Kimble et al. 2013b). Therefore, accurate quantification of drug concentrations in fluid and tissues from eucalypt folivores requires strategies to reduce endogenous compound interference.4.
More on the topic SPECIES EFFECTS ON LABORATORY METHODS:
- SPECIES EFFECTS ON LABORATORY METHODS
- Vogelnest L., Portas T. (Eds.). Current Therapy in Medicine of Australian Mammals. CSIRO,2025. — 848 p., 2025
- REFERENCES
- Compartment, Downer, and Muscle Crush Syndromes of Cattle
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