Thyroid Hormones Are Stored Outside the Cell and Attached to Thyroglobulin in the Form of Colloid
Once thyroid hormones are synthesized, they remain in the extracellular acinar lumen until release. This extracellular storage of hormone within an endocrine gland is a unique storage arrangement.
It allows the thyroid gland to have a large reserve of hormone. From a ideologic standpoint, thyroid hormone is the most important hormone of metabolism; it allows mammals to withstand periods of iodine deprivation without an immediate effect on the production of thyroid hormones.
FIGURE 34-2 Production of tetraiodothyronine (thyronine, T4) and triiodothyronine (T3) by the coupling of iodinated tyrosyl residues with thyroglobulin molecule. DITt Diiodotyrosine; MITt monoiodotyrosine. (From Hedge GA, Colby HD, Goodman RL: Clinical endocrine physiology, Philadelphia, 1987, Saunders.)
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